| Title |
Conditional Cooperativity of Toxin - Antitoxin Regulation Can Mediate Bistability between Growth and Dormancy
|
|---|---|
| Published in |
PLoS Computational Biology, August 2013
|
| DOI | 10.1371/journal.pcbi.1003174 |
| Pubmed ID | |
| Authors |
Ilaria Cataudella, Kim Sneppen, Kenn Gerdes, Namiko Mitarai |
| Abstract |
Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms collectively coined "conditional cooperativity". Toxin and antitoxin form heteromers with different stoichiometric ratios, and the complex with the intermediate ratio works best as a transcription repressor. This allows transcription at low toxin level, strong repression at intermediate toxin level, and then again transcription at high toxin level. Such regulation has two interesting features; firstly, it provides a non-monotonous response to the concentration of one of the proteins, and secondly, it opens for ultra-sensitivity mediated by the sequestration of the functioning heteromers. We explore possible functions of conditional regulation in simple feedback motifs, and show that it can provide bistability for a wide range of parameters. We then demonstrate that the conditional cooperativity in toxin-antitoxin systems combined with the growth-inhibition activity of free toxin can mediate bistability between a growing state and a dormant state. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Belgium | 2 | 1% |
| France | 1 | <1% |
| Malaysia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 127 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 26% |
| Student > Master | 28 | 21% |
| Researcher | 22 | 16% |
| Student > Bachelor | 17 | 13% |
| Student > Doctoral Student | 4 | 3% |
| Other | 15 | 11% |
| Unknown | 13 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 42 | 31% |
| Agricultural and Biological Sciences | 38 | 28% |
| Immunology and Microbiology | 14 | 10% |
| Engineering | 4 | 3% |
| Physics and Astronomy | 4 | 3% |
| Other | 16 | 12% |
| Unknown | 16 | 12% |