Title |
Cooperative Binding
|
---|---|
Published in |
PLoS Computational Biology, June 2013
|
DOI | 10.1371/journal.pcbi.1003106 |
Pubmed ID | |
Authors |
Melanie I. Stefan, Nicolas Le Novère |
Abstract |
Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes. |
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Poland | 1 | 7% |
Japan | 1 | 7% |
Unknown | 4 | 29% |
Demographic breakdown
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---|---|---|
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Scientists | 6 | 43% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 9 | 3% |
Germany | 2 | <1% |
Chile | 1 | <1% |
France | 1 | <1% |
Singapore | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 63 | 18% |
Student > Master | 47 | 13% |
Student > Bachelor | 43 | 12% |
Student > Doctoral Student | 15 | 4% |
Other | 45 | 13% |
Unknown | 61 | 17% |
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---|---|---|
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Agricultural and Biological Sciences | 50 | 14% |
Physics and Astronomy | 25 | 7% |
Engineering | 17 | 5% |
Other | 62 | 17% |
Unknown | 80 | 22% |