Title |
Hemodynamic Traveling Waves in Human Visual Cortex
|
---|---|
Published in |
PLoS Computational Biology, March 2012
|
DOI | 10.1371/journal.pcbi.1002435 |
Pubmed ID | |
Authors |
Kevin M. Aquino, Mark M. Schira, P. A. Robinson, Peter M. Drysdale, Michael Breakspear |
Abstract |
Functional MRI (fMRI) experiments rely on precise characterization of the blood oxygen level dependent (BOLD) signal. As the spatial resolution of fMRI reaches the sub-millimeter range, the need for quantitative modelling of spatiotemporal properties of this hemodynamic signal has become pressing. Here, we find that a detailed physiologically-based model of spatiotemporal BOLD responses predicts traveling waves with velocities and spatial ranges in empirically observable ranges. Two measurable parameters, related to physiology, characterize these waves: wave velocity and damping rate. To test these predictions, high-resolution fMRI data are acquired from subjects viewing discrete visual stimuli. Predictions and experiment show strong agreement, in particular confirming BOLD waves propagating for at least 5-10 mm across the cortical surface at speeds of 2-12 mm s-1. These observations enable fundamentally new approaches to fMRI analysis, crucial for fMRI data acquired at high spatial resolution. |
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Australia | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Cuba | 1 | <1% |
Chile | 1 | <1% |
Australia | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
Other | 1 | <1% |
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Demographic breakdown
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Researcher | 39 | 25% |
Student > Master | 16 | 10% |
Professor > Associate Professor | 8 | 5% |
Professor | 6 | 4% |
Other | 22 | 14% |
Unknown | 19 | 12% |
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Neuroscience | 25 | 16% |
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