Title |
Genome Majority Vote Improves Gene Predictions
|
---|---|
Published in |
PLoS Computational Biology, November 2011
|
DOI | 10.1371/journal.pcbi.1002284 |
Pubmed ID | |
Authors |
Michael E. Wall, Sindhu Raghavan, Judith D. Cohn, John Dunbar |
Abstract |
Recent studies have noted extensive inconsistencies in gene start sites among orthologous genes in related microbial genomes. Here we provide the first documented evidence that imposing gene start consistency improves the accuracy of gene start-site prediction. We applied an algorithm using a genome majority vote (GMV) scheme to increase the consistency of gene starts among orthologs. We used a set of validated Escherichia coli genes as a standard to quantify accuracy. Results showed that the GMV algorithm can correct hundreds of gene prediction errors in sets of five or ten genomes while introducing few errors. Using a conservative calculation, we project that GMV would resolve many inconsistencies and errors in publicly available microbial gene maps. Our simple and logical solution provides a notable advance toward accurate gene maps. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 13% |
Sweden | 1 | 2% |
Germany | 1 | 2% |
Denmark | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 37 | 79% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 36% |
Student > Ph. D. Student | 13 | 28% |
Student > Postgraduate | 4 | 9% |
Student > Bachelor | 3 | 6% |
Professor | 3 | 6% |
Other | 3 | 6% |
Unknown | 4 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 64% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Computer Science | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 3 | 6% |
Unknown | 4 | 9% |