| Title |
Intricate Knots in Proteins: Function and Evolution
|
|---|---|
| Published in |
PLoS Computational Biology, September 2006
|
| DOI | 10.1371/journal.pcbi.0020122 |
| Pubmed ID | |
| Authors |
Peter Virnau, Leonid A Mirny, Mehran Kardar |
| Abstract |
Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Germany | 2 | 1% |
| Italy | 2 | 1% |
| Spain | 2 | 1% |
| Norway | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 158 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 21% |
| Student > Ph. D. Student | 36 | 21% |
| Student > Master | 25 | 14% |
| Student > Bachelor | 19 | 11% |
| Professor > Associate Professor | 12 | 7% |
| Other | 30 | 17% |
| Unknown | 16 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 31% |
| Physics and Astronomy | 30 | 17% |
| Chemistry | 30 | 17% |
| Biochemistry, Genetics and Molecular Biology | 19 | 11% |
| Computer Science | 6 | 3% |
| Other | 18 | 10% |
| Unknown | 18 | 10% |