| Title |
Oscillatory Regulation of Hes1: Discrete Stochastic Delay Modelling and Simulation
|
|---|---|
| Published in |
PLoS Computational Biology, September 2006
|
| DOI | 10.1371/journal.pcbi.0020117 |
| Pubmed ID | |
| Authors |
Manuel Barrio, Kevin Burrage, André Leier, Tianhai Tian |
| Abstract |
Discrete stochastic simulations are a powerful tool for understanding the dynamics of chemical kinetics when there are small-to-moderate numbers of certain molecular species. In this paper we introduce delays into the stochastic simulation algorithm, thus mimicking delays associated with transcription and translation. We then show that this process may well explain more faithfully than continuous deterministic models the observed sustained oscillations in expression levels of hes1 mRNA and Hes1 protein. |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 2 | 1% |
| Mexico | 2 | 1% |
| Chile | 1 | <1% |
| France | 1 | <1% |
| Switzerland | 1 | <1% |
| Portugal | 1 | <1% |
| Japan | 1 | <1% |
| Argentina | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 144 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 31% |
| Researcher | 40 | 25% |
| Student > Master | 12 | 8% |
| Professor | 9 | 6% |
| Student > Bachelor | 6 | 4% |
| Other | 24 | 15% |
| Unknown | 17 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 27% |
| Biochemistry, Genetics and Molecular Biology | 23 | 15% |
| Mathematics | 20 | 13% |
| Computer Science | 15 | 10% |
| Physics and Astronomy | 12 | 8% |
| Other | 23 | 15% |
| Unknown | 22 | 14% |