the approach is described here in Sherman & Cohen's Thermodynamic State Ensemble Models of cis-Regulation. (note the square quotes on 'thermodynamic' in the text) the key assumption is that transcription can be simplified to polymerase concentration

PLoS Computational Biology: Thermodynamic State Ensemble Models of cis-Regulation http://t.co/bco2dAzf

Education: Thermodynamic State Ensemble Models of cis-Regulation http://t.co/bATlgvbi

#PLoS - Thermodynamic State Ensemble Models of cis-Regulation http://t.co/6maGgmqM #science #biology #genomics