“Specifically, many simple MBPs are used hierarchically as a toolkit for the construction of progressively more complex MBPs (data not shown), similar to what has been observed in real metabolic networks." https://t.co/B8iwBrwqC6

“In addition to the recurrence of these topological categories among MBPs, we find that some specific structures are used repeatedly, often in a modular fashion.” https://t.co/B8iwBrwqC6

“It is possible that hallmarks of metabolic optimality in metabolic network wiring may be observable at the level of global (multi-species) metabolic networks more than at the individual species level." https://t.co/B8iwBrwqC6

“Some computational studies have proposed that the topology of specific metabolic pathways may have evolved towards maximal efficiency, minimal number of steps, or that network properties may reflect optimal organization." https://t.co/B8iwBrwqC6

Biochemical networks: “manifold use of certain molecules may be a crucial element of this adaptation, as “it is indeed a general principle of evolution that multiple use is made of given resources." https://t.co/B8iwBrwqC6

“Biochemical network topologies may reflect the adaptation toward optimally efficient metabolic strategies.” https://t.co/B8iwBrwqC6

Metabolic pathways: “the existence of autocatalytic cycles and hierarchical modules, the appearance of universally preferable metabolites and reactions, and a logarithmic trend of pathway length as a function of input/output molecule size." https://t.co/B8

“Despite the simplicity of the model employed, we find that the ensuing pathways display a surprisingly rich set of properties.” https://t.co/B8iwBrwqC6

Metabolic pathways. “Finally, across all optimal pathways, we identify universally important metabolites and reactions, as well as a characteristic distribution of reaction utilization." https://t.co/B8iwBrwqC6

Metabolic pathways. “They also display recurring topologies, including autocatalytic cycles reminiscent of ancient and highly conserved cores of real biochemistry.” https://t.co/B8iwBrwqC6

Metabolic pathways. “We find that optimal pathways in our idealized chemistry display a logarithmic dependence of pathway length on input/output molecule size.” https://t.co/B8iwBrwqC6

“Comparative genomics can provide top-down insight into some long-term evolution of metabolic pathways." https://t.co/B8iwBrwqC6

“Especially during major transitions, such as the early stages of life's appearance or the rise of oxygen in the Earth's atmosphere, selective forces must have shaped the metabolic wiring itself.“ https://t.co/B8iwBrwqC6

“Different organisms have different assortments of metabolic pathways and input/output requirements, reflecting their adaptation to specific environments, and to specific strategies for reproduction and survival." https://t.co/B8iwBrwqC6

“Metabolism is the network of biochemical reactions that transforms available resources (“inputs”) into energy currency and building blocks (“outputs”).” https://t.co/B8iwBrwqC6

“Here we ask whether, beneath the intricate wiring of these networks, it is possible to discern signatures of optimal (i.e., shortest and maximally efficient) pathway architectures." https://t.co/B8iwBrwqC6

“Is the evolution of metabolism subject to general principles, beyond the unpredictable accumulation of multiple historical accidents?“ https://t.co/B8iwBrwqC6