@CeciliaNordens1 https://t.co/itulRMga7v Please note that ZIP proteins harboring CFC sequences N-terminal to their transmembrane domains can be found in organisms with relatively primitive body plans such as hydra (H. magnipapillata)
"Modern-day prion proteins as remnants of an ancient involvement in the sensing and/or import of metal ions." https://t.co/uT3PPz1eD2
"This finding provides a rationale for structural and biological features within modern-day prion proteins." https://t.co/uT3PPz1eD2
"The prion gene family is phylogenetically derived from a ZIP-like ancestral molecule." https://t.co/uT3PPz1eD2
Homologies reveal "the unexpected presence of a PrP-like amino acid sequence within...the ZIP protein family." https://t.co/uT3PPz1eD2
"We...identify the function of the cellular prion protein through a comprehensive interactome investigation." https://t.co/uT3PPz1eD2
"The function of a protein can sometimes be deduced by characterizing its binding partners." https://t.co/uT3PPz1eD2
"Most proteins do not act in isolation but partner with other proteins to exert their biological roles." https://t.co/uT3PPz1eD2