https://t.co/VFaZxsM0mb "such as interferon (IFN)-β (35 fold), tumor necrosis factor (TNF)-α (9.7 fold), and interleukin (IL)-6 (11.3 fold) (p<0.01)."
https://t.co/VFaZxsMybJ "The results showed that in primary human cells, or in mice, 10% ss-Ino-RNA rapidly and potently induced a significant increase in inflammatory cytokines,"
https://t.co/VFaZxsM0mb "Here we report that ss-Ino-RNA is a novel viral recognition element. We synthesized unmodified ssRNA and ssRNA that had 6% to16% inosine residues."
https://t.co/VFaZxsM0mb "The cellular enzyme ADAR-1 (adenosine deaminase acting on RNA-1) activation in virally infected cells leads to presence of inosine-containing RNA (Ino-RNA)."
Inosine-Containing RNA Is a Novel Innate Immune Recognition Element and Reduces RSV Infection https://t.co/VFaZxsMybJ
@Steffen_E_Fuchs @Stoibs11 @nanopore I found this paper on what type of modifications/bases you would expect 2 c after a RNA virual infection. https://t.co/RqN3yuJXts
@trvrb @GISAID @nextstrain Are these variants due to RNA editing by any chance or possibly due to the presence of Inosine which hasn't been picked up yet ?https://t.co/RqN3yusmBU
Inosine-Containing RNA Is a Novel Innate Immune Recognition Element and Reduces RSV Infection http://t.co/OX6GETdS