@kristenobacter @merenbey @malladapted @NSF @jgi @HarvardForest Did you see any differences in nucleotide frequencies (1-mers/2-mers) or proportion of thermostable amino acids (e.g. Zeldovich 2007 https://t.co/7K4NO6VLG3)?
@daanspeth I'm curious...did you try the Zeldovich method as well? It's very simple and seems to give higher OGT predictions than Tome. Would be interesting to know how it compares to Sauer. https://t.co/JnUuiMI39U
@daanspeth We have been trying the following two methods: https://t.co/JnUuiMI39U and https://t.co/eYS2OWvXjt
@arneelof Looks very interesting. Might be worth comparing to work from Shahknovich on effects of growth temperature on AA bias (e.g. https://t.co/iJC8dQDTC2) and suggestions that R->K might help stabilize proteins in thermophiles? (https://t.co/iDmG1OH
Comment on Zeldovich KB (2007): Protein and DNA sequence determinants of thermophilic adaptation. https://t.co/zrlTO4GMbA
More details about "molecular thermometer" in this @PLOSCompBiol paper #smbe15 Gouy http://t.co/ttPsrQdEDj
More details about "molecular thermometer" in this @PLOSCompBiol paper #smbe15 Gouy http://t.co/ttPsrQdEDj
More details about "molecular thermometer" in this @PLOSCompBiol paper #smbe15 Gouy http://t.co/ttPsrQdEDj
More details about "molecular thermometer" in this @PLOSCompBiol paper #smbe15 Gouy http://t.co/ttPsrQdEDj
More details about "molecular thermometer" in this @PLOSCompBiol paper #smbe15 Gouy http://t.co/ttPsrQdEDj
MG: also correlation between AA composition and optimal growth temp. http://t.co/1JJTC7GRZc #smbe15
More details about "molecular thermometer" in this @PLOSCompBiol paper #smbe15 Gouy http://t.co/ttPsrQdEDj
McDonald pub in last tweet points out serious (and cool) #phylogenetics flaw in this, earlier, paper on #proteomes: http://t.co/Y9EqVKxeMP