RT @boris_ctcf: The US Patent # 8,440,415 is based on the following publication by Elena Pugacheva et. al.: The Structural Complexity of tโฆ
The US Patent # 8,440,415 is based on the following publication by Elena Pugacheva et. al.: The Structural Complexity of the Human BORIS Gene in Gametogenesis and Cancer (2010) PLoS ONE 5(11): e13872. https://t.co/Qi7U6GwF1a https://t.co/EPvHj
Most, if not all, alternatively spliced isoforms of CTCF Like human BORIS CTA listed in the USA Patent https://t.co/q5uvIJKB71 have been originally published over 12 years ago by Elena Pugacheva et. al. on the BORIS Complexity in Gametogenesis and Cancer
The Structural Complexity of the Human BORIS Gene in Gametogenesis and Cancer https://t.co/QNbl32lGVr https://t.co/PIn31fYBse
Note the NOVEL "Hybrid C2H2" finger" formed in the Open Reading Frame (ORF) of the C6 mRNA isoform through an alternative but precise joining of two distant CTCF or BORIS exons with w.t. ORFs coding for the CxxCxxxxxx-//-half of ZF#4 and x-//-xxxxHxxxH hal
The Structural Complexity of the Human CTCFLike BORIS Gene in Gametogenesis and Cancer. It is expressed in 23 isoforms in both germ and cancer cells. Each form is comprised of alternative N- & C-termini joined with varying ZnFs in distinct CTCF like DB
The structural complexity of the human BORIS gene in gametogenesis and cancer. - PubMed - NCBI https://t.co/HKpiW3Mehm
RT @boris_ctcf: Phylogenetic analyses of 2 paralogous members of CTCF family revealed remarkable evolutionary burst of alternative splicingโฆ
Phylogenetic analyses of 2 paralogous members of CTCF family revealed remarkable evolutionary burst of alternative splicing in the 2nd CTCF-derived CTCFL/BORIS locus co-expressed w/CTCF during gametogenesis in 23 isoforms conserved from primates to humans
The structural complexity of the human BORIS gene in gametogenesis and cancer. - PubMed - NCBI https://t.co/HKpiW3Mehm
#boris_ctcf Good read. https://t.co/1yLyFKw1iw
Unlike 11ZF ORF/Exons of CTCF/16q22 locus, paralogous 11ZF Exons in BORIS/20q13 locus undergo complex Alt.Splicing - https://t.co/DXpUFAKMnl