https://t.co/fLnRfqN76I The presence of self-reactive IgG autoantibodies in human sera is largely thought to represent a breakdown in central tolerance and is typically regarded as a harbinger of autoimmune pathology. Min Han 所有人血清中都富含 IgG 自身抗體 通血管/降血壓/
https://t.co/gGRk1KC29s IgG autantibodies are found in all humans. What are they doing? Which are pathological and which are not? Important to ponder, especially around diagnostics for neurological disease #neuropathy
@anonymous_leeks @fitterhappierAJ … viruses to remain. We can clear the virus itself, but the tissue damage itself remains self-fulfilling and chronic. Try this for consideration: https://t.co/AnzHCEKsFP
@hjelle_brian Sincere question: From your perspective, if “innate” lacks memory, why do we have fairly constant autoAb profiles throughout life, for “housekeeping”? Does that fall under Bs? https://t.co/AnzHCEKsFP
@fitterhappierAJ @Reroot_Flyover Individual benefits relative to people with no memory. That should be obvious from the context. We should strive to vaccinate people to obtain memory that way vs natural infection, but I would worry more about the immunolog
@AltGovDoc Before I do, though, y’all have homework. Read this paper. Then come back, sit down, bring snacks, and I’ll give you a lesson. https://t.co/AnzHCEKsFP
@BrodinPetter Can't wait til we add antigen-specificity to longitudinal studies like this. Cool paper here showing the bulk 'fingerprint' of autoantibodies is pretty stable over the years, but in a cohort like yours could see new infections via VirScan PhI
RT @EmbryoResist: @alt_fda ... continues. This is true of nearly any disease, particularly chronic ones. Apoptosis and necrosis drive it;…
@alt_fda ... continues. This is true of nearly any disease, particularly chronic ones. Apoptosis and necrosis drive it; housekeeping can’t keep up. Here’s how we know: https://t.co/AyP5bKWM8o
RT @DamanLangguth: Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and…
@KetoCarnivore @HastaVictoriaS1 We have autoimmunity - a very very unique autoantibody immunity - to a big chunk of the human proteome. It appears 'harmless' and increases with age / experience: https://t.co/oDnY44ifC3
@Crypt0_Donkey @joerogan @YouTube It's an opinion - maybe wrong - based on reading thousands of papers, and incorporating anecdotes like this. We all have 'natural' antibodies to a huge percent of our normal proteins. IE background autoimmunity that seems
"serum IgG autoantibody profiles are unique to an individual and remarkably stable over time" http://t.co/oGPECXJgIw | #rationale
http://t.co/fQb9oITYxf ..methods/ideas for inducible triggering of autoimmunity required in mouse models of human diseases.