@NKWhiteman Curiously, these protective effects are still far from understood. We screened for caffeine-sensitive mutants when I first started my lab and …after a long, long time, figured out that the genes affected were somehow related to DNA repair. htt
@NKWhiteman You could always try to figure out more about the coffee-cancer phenomenon, like we did a few (!) years ago…https://t.co/i9AUe1NLq9
@WallaceUcsf I think it’s because of functional redundancy among different repair pathways. We ran into this when we screened for caffeine-sensitive mutants that affect the SMC5/6 complex. https://t.co/nRrUoIMSBa
@lauragcwall @drdagly Yes, finally! @drdagly Here is the article about caffeine-sensitive fruit fly mutants: https://t.co/nRrUoIuJn2
@ConversationCA @tjsmerritt @LaurentianU Have you seen this one? https://t.co/nRrUoIuJn2
The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. http://t.co/t0i5xxnAE0
science contribution: caffeine-induced apoptosis in mutants exacerbated by inhibition of ATM, ATR checkpoint kinases http://t.co/h5H6DwX9fy