RT @awjuliani: I have a mystery (perhaps from of my own ignorance) regarding: "Psychedelics and the Human Receptorome" (https://t.co/0mce1D…

RT @awjuliani: I have a mystery (perhaps from of my own ignorance) regarding: "Psychedelics and the Human Receptorome" (https://t.co/0mce1D…

RT @awjuliani: I have a mystery (perhaps from of my own ignorance) regarding: "Psychedelics and the Human Receptorome" (https://t.co/0mce1D…

RT @awjuliani: I have a mystery (perhaps from of my own ignorance) regarding: "Psychedelics and the Human Receptorome" (https://t.co/0mce1D…

I have a mystery (perhaps from of my own ignorance) regarding: "Psychedelics and the Human Receptorome" (https://t.co/0mce1DL5DH), which many cite as the definitive receptor affinity profile for psychedelics. Maybe someone can provide the answer? Accordi

@zenbrainest Yet 5-MeO-DMT has a 1000X greater affinity for 5-HT1A over 5-HT2a? And, do mGluRs also play a role in 5-MeO-DMT action? https://t.co/nOQyycmwf9 https://t.co/lFxv8jFhsH

LSD is stronger so it is easier to get a high dose than with psilocybin. Psilocybin has the best safety record---why Johns Hopkins chose it. Ray's paper can give you some insight into differences if you dive into the neuro aspect. https://t.co/91Xoij0eJ

@iLENS Would love a more recent one https://t.co/dwClwYDTAF

@whakaaro https://t.co/dwClwYDTAF

@jennyalaking We need a more recent one than this from 2010 but this is pretty epic! https://t.co/dwClwYDTAF

RT @cube_flipper: @Josikinz @nat_sharpe_ receptor affinities of LSD and psilocin: (from https://t.co/svQSqGPgGa) https://t.co/Q7rPLC5iir

@Josikinz @nat_sharpe_ receptor affinities of LSD and psilocin: (from https://t.co/svQSqGPgGa) https://t.co/Q7rPLC5iir

Even more interesting is the potential to combine neurophenomenology with pharmacophenomenology to develop a neuropharmacophenomenology, as in https://t.co/THPohIp9pv.

In the context of psychedelics and entactogens, I believe pharmacophenomenology will also prove to be important. @MindstateDesign is pursuing this approach commercially. Some early work in this area: https://t.co/Hctw1iMXd3, https://t.co/CF6MVcl9XY, https:

@ryanhellyer @RCarhartHarris receptor profile is similar, but not identical (https://t.co/gbMqU6mb8A), so there is space for differences. Also, as highlighted in the thread, this finding may be explained by the imbalanced sample size. Hope this paper inspi

RT @therealbrom: 5ht2a and 5ht2b receptor binding affinities for different psychedelic drugs (lower number = more binding) data from Tom…

5ht2a and 5ht2b receptor binding affinities for different psychedelic drugs (lower number = more binding) data from Tom Ray: https://t.co/OnueRiE1bw https://t.co/OtoC1fheSd

@FatherMcKennaa pretty hard to test without running a long term study. luckily for the ayahuasceros, DMT doesn't bind to 5ht2b with the same strength as psilocin (according to Tom Ray's data) https://t.co/OnueRiEz14

Phenomenal paper. #psychedelics #receptors Psychedelics and the Human Receptorome https://t.co/A9pHqq6Jhy

@mattbagg not necessarily, but the evidence is quite against it so far, eg see this source (which is where my data was from) note also they do have a normalized affinity measure, which takes into account relative affinities at different receptors https://

#Psychedelics and the Human Receptorome: https://t.co/Lf1bYdI8oC #psilocybin #psilocybinresearch

@BasicMorality Based on Tomas Ray work on receptor affinity, that would perhaps make DOI the most promising anti-tolerance psychedelic. What do you think? It also has relatively low 5HT2b affinity, which I like as that's the one receptor associated with ca

https://t.co/lD8rO45RF4

PLOS ONE | Psychedelics and the Human Receptorome https://t.co/z3x65DSBRD

http://t.co/IClO1RA7vz

interesting... http://t.co/HHdwJacbMW