BHD pulmonary cysts: The stretch hypothesis
Birt-Hogg-Dubé Syndrome,
The majority of BHD patients develop pulmonary cysts and approximately 1 in 3 will suffer a pneumothorax. Although BHD…
BHD pulmonary cysts: The stretch hypothesis
BHD Research,
The majority of BHD patients develop pulmonary cysts and approximately 1 in 3 will suffer a pneumothorax. Although BHD…
BHD pulmonary cysts: The stretch hypothesis
Research Blogging - All Topics - English,
The majority of BHD patients develop pulmonary cysts and approximately 1 in 3 will suffer a pneumothorax. Although BHD…
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Birt-Hogg-Dubé Syndrome,
The FLCN…
BHD lung cysts are not degenerative, but may cause pneumothorax
BHD Research,
Although 90% of BHD patients develop lung cysts, there is very little information about the natural history of BHD lung cysts.
BHD lung cysts are not degenerative, but may cause pneumothorax
Birt-Hogg-Dubé Syndrome,
Although 90% of BHD patients develop lung cysts, there is very little information about the natural history of BHD lung cysts.
FLCN is necessary for the survival and function of Type II alveolar epithelial cells
BHD Research,
Roughly 90% of BHD patients develop lung cysts, which are thought to also cause spontaneous pneumothorax in 1 in 4 BHD patients …
FLCN is necessary for the survival and function of Type II alveolar epithelial cells
Birt-Hogg-Dubé Syndrome,
Roughly 90% of BHD patients develop lung cysts, which are thought to also cause spontaneous pneumothorax in 1 in 4 BHD patients …
FLCN’s roles in RhoA and mTOR signalling may be part of a single, larger signalling pathway
Birt-Hogg-Dubé Syndrome,
FLCN has been previously reported to regulate both mTOR and RhoA signalling. Although currently considered to be two unrelated…
FLCN’s roles in RhoA and mTOR signalling may be part of a single, larger signalling pathway
BHD Research,
FLCN has been previously reported to regulate both mTOR and RhoA signalling. Although currently considered to be two unrelated…
FLCN’s roles in RhoA and mTOR signalling may be part of a single, larger signalling pathway
Birt-Hogg-Dubé Syndrome,
FLCN has been previously reported to regulate both mTOR and RhoA signalling. Although currently considered to be two unrelated…
FLCN may control cell-cell adhesion via PKP4 and Rab11a
BHD Research,
In 2012, two separate studies reported that FLCN interacts with Plakophilin4 (PKP4) to regulate RhoA signalling and cell-cell…
FLCN may control cell-cell adhesion via PKP4 and Rab11a
Birt-Hogg-Dubé Syndrome,
In 2012, two separate studies reported that FLCN interacts with Plakophilin4 (PKP4) to regulate RhoA signalling and cell-cell…
Heterozygous loss of FLCN may cause cyst development by making alveolar walls more vulnerable to mechanical stress
BHD Research,
Lung cysts are a highly penetrant symptom of BHD Syndrome, affecting up to 90% of patients, yet the mechanism of how they…
Heterozygous loss of FLCN may cause cyst development by making alveolar walls more vulnerable to mechanical stress
Birt-Hogg-Dubé Syndrome,
Lung cysts are a highly penetrant symptom of BHD Syndrome, affecting up to 90% of patients, yet the mechanism of how they…
Video interview: Dr Douglas Medvetz, Brigham and Women’s Hospital, USA
BHD Research,
This week we would like to introduce you to the work of Dr Douglas Medvetz, a Post-Doctoral Research Fellow in Professor…
Video interview: Dr Douglas Medvetz, Brigham and Women’s Hospital, USA
Birt-Hogg-Dubé Syndrome,
This week we would like to introduce you to the work of Dr Douglas Medvetz, a Post-Doctoral Research Fellow in Professor…
Video interview: Professor Lisa Henske, Brigham and Women’s Hospital, USA
Science Blog,
This week we would like to introduce you to the work of Professor Elizabeth Henske, Founding Director of the Centre for LAM…
Video interview: Professor Lisa Henske, Brigham and Women’s Hospital, USA
BHD Research,
This week we would like to introduce you to the work of Professor Elizabeth Henske, Founding Director of the Centre for LAM…
Video interview: Professor Lisa Henske, Brigham and Women’s Hospital, USA
Birt-Hogg-Dubé Syndrome,
This week we would like to introduce you to the work of Professor Elizabeth Henske, Founding Director of the Centre for LAM…
FLCN delays cell cycle progression
BHD Research,
The cell cycle is tightly regulated and necessary for development, growth and tissue replacement and repair. The process…
FLCN delays cell cycle progression
Birt-Hogg-Dubé Syndrome,
The cell cycle is tightly regulated and necessary for development, growth and tissue replacement and repair. The process…
Birt-Hogg-Dubé syndrome is a novel ciliopathy
BHD Research,
Cilia are thin protuberances emanating from eukaryotic cells. Cilia fall in to two categories: primary and motile. Primary…
Birt-Hogg-Dubé syndrome is a novel ciliopathy
Birt-Hogg-Dubé Syndrome,
Cilia are thin protuberances emanating from eukaryotic cells. Cilia fall in to two categories: primary and motile. Primary…
Video Interview: Professor Vera Krymskaya – University of Pennsylvania, USA
Birt-Hogg-Dubé Syndrome,
This week we would like to introduce you to the work of Professor Vera Krymskaya, Associate Professor of Medicine at the…
BHD and apoptosis: a review
Science Blog,
Last week’s blog described a recent paper by Sano et al., which showed that FNIP2 is required for apoptosis in [...]
BHD and apoptosis: a review
Birt-Hogg-Dubé Syndrome,
Last week’s blog described a recent paper by Sano et al., which showed that FNIP2 is required for apoptosis in human cells.
BHD Research Blog: 2012 Annual Review
Science Blog,
With the New Year upon us, we thought we would use this week’s blog to revisit those studies we’ve particularly [...]
BHD Research Blog: 2012 Annual Review
Birt-Hogg-Dubé Syndrome,
With the New Year upon us, we thought we would use this week’s blog to revisit those studies we’ve particularly enjoyed reading…
Research involving Rab35 and Rab27B
Birt-Hogg-Dubé Syndrome,
As discussed in a previous blog post, the Rab family of small GTPases are known to be involved in membrane trafficking. Two…
Microarray analysis identifies potential FLCN targets
Birt-Hogg-Dubé Syndrome,
Although FLCN has been shown to function in several biological pathways, such as mTOR and AMPK signalling (as illustrated in…
The role of FLCN in RhoA signalling and cell-cell adhesion
Birt-Hogg-Dubé Syndrome,
As discussed in a previous blog post, Plakophilin-4 (PKP4) is a recently discovered FLCN interactor that regulates RhoA…
BHD Literature Database Updated
Birt-Hogg-Dubé Syndrome,
The BHD Literature Database has been updated with two research papers. Medvetz et al. report that FLCN interacts with…