Candidate longevity genes. “We confirm 30 new LAGs identified through network analysis of C. elegans and human candidates.” https://t.co/gnIOxHBdYW

Candidate longevity genes. “We longitudinally confirmed 11 positive regulators of lifespan; these genes decrease C. elegans longevity when inactivated post-developmentally.“ https://t.co/gnIOxHBdYW

Candidate longevity genes. “Our primary analysis, 156 of these inactivations resulted in extended (101) or decreased (55) lifespan. We confirmed a subset (30 genes) of these phenotypes in rigorous longitudinal analyses.” https://t.co/gnIOxHBdYW

“The partners of known LAGs in the worm and human longevity networks may participate in the intricate pathways and complexes that regulate lifespan, and are therefore candidate longevity genes.“ https://t.co/gnIOxHBdYW

Stress genes and longevity. “The post-reproductive decrescendo of the force of natural selection permits the evolution of genes that are essential early in life but detrimental late in life.” https://t.co/gnIOxHBdYW

Stress genes can increase longevity. “This finding appears to illustrate the antagonistic pleiotropy theory of aging.” https://t.co/gnIOxHBdYW

RT @TenFleming: “Known longevity genes are enriched for roles in stress tolerance and development.” https://t.co/gnIOxHBdYW

Stress genes. “Overexpression of most of these genes extends lifespan and, where tested, increases stress tolerance” https://t.co/gnIOxHBdYW

C. elegans mutants.”Many genes required for the successful extension of lifespan in one or more long-lived mutants also contribute to the longevity of wild-type animals, but are distinguished by a proportionally greater change in the mutant background.” ht

“A study of over 50 long-lived C. elegans mutants reveals that each is resistant to one or more stressors, such as oxidative damage, heat stress or irradiation.” https://t.co/gnIOxHBdYW

“Many mutations that modulate longevity were identified by virtue of their contribution to stress response pathways or by homology to genes of this kind.” https://t.co/gnIOxHBdYW

“Known longevity genes are enriched for roles in stress tolerance and development.” https://t.co/gnIOxHBdYW

“The worm and human longevity networks are functionally relevant and possess a high predictive power for identifying new longevity regulators.” https://t.co/gnIOxHBdYW

“Many important longevity genes likely remain unidentified.” https://t.co/gnIOxHBdYW

“Curran and Ruvkun explored this overlooked gene set by inactivating essential genes postdevelopmentally, revealing 64 genes required for development that extend lifespan when inactivated during adulthood.“ https://t.co/gnIOxHBdYW

“Because biological processes are often executed by protein complexes and fine-tuned by regulatory factors, the first-order protein-protein interactors of known longevity genes are likely to participate in the regulation of longevity.” https://t.co/gnIOxHB

Prediction of C. elegans longevity genes by human and worm longevity networks. http://t.co/riNEuIu5JE

Prediction of C. elegans longevity genes by human and worm longevity networks http://t.co/gsY1R1nW